Writing and Research

Posts

Growth Signals — Cofounder and CSO. I lead all data science and AI research for a GenAI platform purpose-built for R&D and Innovation teams.
Moderna Therapeutics — I was the first Data Scientist at Moderna and grew the Data Science and AI team from the ground up. My work focused on applying machine learning and statistical techniques to improve mRNA medicines, and on software engineering for ML and generative AI platforms.
Harvard Medical School — Ph.D. with Bernardo Sabatini (synaptic signaling in hippocampal neurons); postdoc in Sandeep Datta’s lab (olfactory system).

gptel-otel — OpenTelemetry tracing for gptel requests, tools, and subagents in Emacs. Open source. 2026.
Semantic Scholar MCP — A maintained fork exposing Semantic Scholar's API as tools for literature search, citations, and references. Open source. 2026.
Cathedral — Church-inspired probabilistic programming and Bayesian inference in Python. Open source. 2026.
SeqLike — Flexible biological sequence objects in Python. Open source; docs. 2021.

Giessel A, Dousis A, Ravichandran K, et al. Therapeutic enzyme engineering using a generative neural network. Sci Rep 2022.
Giessel AJ, Datta SR. Olfactory Maps, Circuits and Computations. Curr Opin Neurobiol 2014.
Carter BC, Giessel AJ, Sabatini BL, Bean BP. Transient sodium current at subthreshold voltages. Neuron 2012.
Giessel AJ, Sabatini BL. Boosting of synaptic potentials and spine Ca transients by SNX-482 requires alpha-1E-encoded voltage-gated Ca channels. PLoS One 2011.
Giessel AJ, Sabatini BL. M1 muscarinic receptors boost synaptic potentials and calcium influx in dendritic spines by inhibiting postsynaptic SK channels. Neuron 2010.
Bloodgood BL, Giessel AJ, Sabatini BL. Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spines. PLoS Biol 2009.
Richter ML, Samra HS, He F, Giessel AJ, Kuczera KK. Coupling proton movement to ATP synthesis in the chloroplast ATP synthase. J Bioenerg Biomembr 2005.